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Coronaviruses are important human and animal pathogens. At the end of 2019, a novel coronavirus was identified as the cause of a cluster of pneumonia cases in Wuhan, a city in the Hubei Province of China. It rapidly spread, leading to a global pandemic. In February 2020, the World Health Organization designated the disease COVID – 19, which stands for coronavirus disease 2019.. The virus that causes COVID – 19 is designated as severe acute respiratory syndrome coronavirus 2 ( SARS–CoV–2 ). Like other viruses, SARS-CoV-2 evolves over time. Certain variants have garnered widespread attention because of their rapid emergence within populations and evidence for transmission or clinical implications;